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Original Research Article | OPEN ACCESS

Protective effect of Polygala tenuifolia Willd extract on Alzheimer disease in rats

Guo-jing Jiang1, Xin Li1 , Yan-qiu Deng2

1Department of Neurology, The Second Hospital of Tianjin Medical University; The Branch of Tianjin Third Central Hospital; 2Pathology Physiology Teaching Room Of Basic Medical School, Tianjin Medical University, Tianjin 300211, China.

For correspondence:-  Xin Li   Email: lixin494@126.com   Tel:+862288328514

Accepted: 19 June 2019        Published: 29 July 2019

Citation: Jiang G, Li X, Deng Y. Protective effect of Polygala tenuifolia Willd extract on Alzheimer disease in rats. Trop J Pharm Res 2019; 18(7):1513-1518 doi: 10.4314/tjpr.v18i7.22

© 2019 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To investigate the protective effect of Polygala tenuifolia Willd extract (PTWE) against Alzheimer disease in 3xTg-AD mice.
Method: The cognitive function of 3xTg-AD mice was assessed using the Morris water maze test. The levels of the amyloid beta deposits and NeuN in the hippocampus were evaluated by immunohistochemistry. Brain neurotrophic derived factor (BDNF) and tyrosine kinase B (TrkB) expressions were examined by western blot analysis.
Results: PTWE treatment significantly ameliorated learning and memory deficits in AD mice, as shown by increased time spent in the target zone during probe tests. The escape latency in animals treated with 340 mg/kg PTWE (22.3 ± 1.5 s) was significantly increased when compared to 3xTg-AD mice (11.8 ± 1.2 s, p < 0.01). In addition, PTWE significantly decreased Aβ deposits, increased NeuN-positive cells, and upregulated the expressions of BDNF (1.5 ± 0.3, p < 0.05) and TrkB (1.3 ± 0.3, p < 0.05) in 3xTg AD mice.
Conclusion: The findings indicate that PTWE treatment may be a useful strategy for treating memory impairment induced by several neurodegenerative diseases.

Keywords: Polygala tenuifolia, Alzheimer disease, Neurodegeneration, Memory impairment, Amyloid beta deposits

Impact Factor
Thompson Reuters (ISI): 0.523 (2021)
H-5 index (Google Scholar): 39 (2021)

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